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| 2 RFEF 5 | 12.09.2021 | CD Marchamalo | - | UD Melilla | 0:0 | ??? |
| 2 RFEF 5 | 26.09.2021 | CD Marchamalo | - | Atlético Mancha Real | 0:0 | ??? |
| 2 RFEF 5 | 10.10.2021 | CD Marchamalo | - | CS Puertollano CF | 0:0 | ??? |
| 2 RFEF 5 | 17.10.2021 | CD Marchamalo | - | Granada B | 0:1 | ??? |
| 2 RFEF 5 | 31.10.2021 | CD Marchamalo | - | Mar Menor CF | 2:0 | ??? |
| 2 RFEF 5 | 14.11.2021 | CD Marchamalo | - | UD Socuéllamos | 1:2 | ??? |
| 2 RFEF 5 | 27.11.2021 | CD Marchamalo | - | Atlético Levante | 1:7 | ??? |
| Copa del Rey | 30.11.2021 | CD Marchamalo | - | Valladolid | 0:1 | ??? |
| 2 RFEF 5 | 12.12.2021 | CD Marchamalo | - | CF La Nucía | 0:3 | ??? |
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