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| 2 RFEF 4 | 05.09.2021 | Xerez DFC | - | Córdoba | 1:5 | ??? |
| 2 RFEF 4 | 19.09.2021 | Xerez DFC | - | CF Villanovense | 2:0 | ??? |
| 2 RFEF 4 | 03.10.2021 | Xerez DFC | - | Las Palmas Atlético | 2:1 | ??? |
| 2 RFEF 4 | 17.10.2021 | Xerez DFC | - | AD Ceuta FC | 2:2 | ??? |
| 2 RFEF 4 | 07.11.2021 | Xerez DFC | - | Cádiz CF B | 0:1 | ??? |
| 2 RFEF 4 | 21.11.2021 | Xerez DFC | - | Don Benito | 1:0 | ??? |
| Copa del Rey | 02.12.2021 | Xerez DFC | - | Leganés | 1:2 | ??? |
| 2 RFEF 4 | 05.12.2021 | Xerez DFC | - | UD San Fernando | 1:0 | ??? |
| 2 RFEF 4 | 19.12.2021 | Xerez DFC | - | Antequera CF | 1:0 | ??? |
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