| 2. Jornada | 20.08.2021 | KVC Westerlo | - | RWD Molenbeek | 0:0 |  |
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| 6. Jornada | 25.09.2021 | RWD Molenbeek | - | Lommel SK | 1:2 | ||||
| 7. Jornada | 03.10.2021 | SK Deinze | - | RWD Molenbeek | 1:2 | ||||
| 8. Jornada | 17.10.2021 | RWD Molenbeek | - | KVC Westerlo | 1:2 | ||||
| 9. Jornada | 22.10.2021 | Royal Excel Mouscron | - | RWD Molenbeek | 1:1 |  |
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| 10. Jornada | 31.10.2021 | Lommel SK | - | RWD Molenbeek | 2:3 | |
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| 11. Jornada | 07.11.2021 | RWD Molenbeek | - | Lierse Kempenzonen | 3:3 | |
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| 12. Jornada | 21.11.2021 | Excelsior Virton | - | RWD Molenbeek | 0:2 | ||||
| 13. Jornada | 28.11.2021 | RWD Molenbeek | - | SK Deinze | 2:2 | ||||
| 14. Jornada | 04.12.2021 | Waasland-Beveren | - | RWD Molenbeek | 2:3 | |
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| 15. Jornada | 25.01.2022 | RWD Molenbeek | - | KVC Westerlo | 0:2 | ||||
| 19. Jornada | 06.02.2022 | Excelsior Virton | - | RWD Molenbeek | 0:1 | ||||
| 20. Jornada | 13.02.2022 | RWD Molenbeek | - | SK Deinze | 1:0 | ||||
| 27. Jornada | 09.04.2022 | RWD Molenbeek | - | Waasland-Beveren | 2:1 |
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