| 5. Jornada | 08.08.2021 | Minnesota United FC | - | Houston Dynamo | 2:0 | ||||
| 5. Jornada | 15.08.2021 | Houston Dynamo | - | Colorado Rapids | 1:3 | ||||
| 5. Jornada | 19.08.2021 | Real Salt Lake | - | Houston Dynamo | 2:1 | ||||
| 5. Jornada | 22.08.2021 | Houston Dynamo | - | FC Dallas | 2:2 | ||||
| 5. Jornada | 29.08.2021 | Houston Dynamo | - | Minnesota United FC | 1:2 |  |
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| 7. Jornada | 17.10.2021 | Houston Dynamo | - | Seattle Sounders | 2:1 | ||||
| 7. Jornada | 21.10.2021 | Houston Dynamo | - | Los Angeles Galaxy | 0:3 | ||||
| 7. Jornada | 24.10.2021 | Austin FC | - | Houston Dynamo | 2:1 | ||||
| 7. Jornada | 31.10.2021 | Houston Dynamo | - | Colorado Rapids | 0:1 |  |
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| 8. Jornada | 04.11.2021 | CF Montréal | - | Houston Dynamo | 2:0 | |
Panamá