| 2. Jornada | 13.02.2022 | Sporting San Miguelito | - | Plaza Amador | 1:1 | ||||
| 4. Jornada | 27.02.2022 | Alianza | - | Sporting San Miguelito | 0:1 | ||||
| 5. Jornada | 05.03.2022 | Sporting San Miguelito | - | Potros del Este | 1:1 | ||||
| 6. Jornada | 08.03.2022 | UD Universitario | - | Sporting San Miguelito | 0:2 | ||||
| 7. Jornada | 13.03.2022 | Sporting San Miguelito | - | Herrera FC | 1:1 | ||||
| 9. Jornada | 26.03.2022 | San Francisco FC | - | Sporting San Miguelito | 0:1 | ||||
| 10. Jornada | 04.04.2022 | Sporting San Miguelito | - | Atlético Chiriquí | 4:1 | ||||
| 11. Jornada | 09.04.2022 | Sporting San Miguelito | - | Independiente de La Chorrera | 2:1 | ||||
| 13. Jornada | 23.04.2022 | Plaza Amador | - | Sporting San Miguelito | 1:1 | ||||
| 14. Jornada | 27.04.2022 | Sporting San Miguelito | - | Árabe Unido | 1:0 | ||||
| 15. Jornada | 30.04.2022 | Sporting San Miguelito | - | Alianza | 1:0 |
Panamá