| 4. Jornada | 12.08.2018 | Deportivo Guadalajara [Sub 20] | - | Santos Laguna [Sub 20] | 3:0 | ||||
| 5. Jornada | 19.08.2018 | Santos Laguna [Sub 20] | - | UANL Tigres [Sub 20] | 3:3 | ||||
| 7. Jornada | 27.08.2018 | Santos Laguna [Sub 20] | - | Cruz Azul [Sub 20] | 2:0 | ||||
| 8. Jornada | 02.09.2018 | Deportivo Toluca [Sub 20] | - | Santos Laguna [Sub 20] | 3:2 | ||||
| 9. Jornada | 14.09.2018 | Santos Laguna [Sub 20] | - | Club León [Sub 20] | 3:4 | ||||
| 10. Jornada | 23.09.2018 | Santos Laguna [Sub 20] | - | CD Veracruz [Sub 20] | 1:0 | ||||
| 11. Jornada | 29.09.2018 | Club Necaxa [Sub 20] | - | Santos Laguna [Sub 20] | 1:3 |  |
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| 12. Jornada | 05.10.2018 | Santos Laguna [Sub 20] | - | Atlas Guadalajara [Sub 20] | 4:3 | ||||
| 17. Jornada | 25.11.2018 | Pumas UNAM [Sub 20] | - | Santos Laguna [Sub 20] | 4:0 |
México