| 8. Jornada | 17.03.2021 | Marathón | - | Vida | 1:2 | ||||
| 9. Jornada | 21.03.2021 | Real España | - | Marathón | 2:2 | ||||
| 10. Jornada | 03.04.2021 | Marathón | - | Platense | 1:0 | ||||
| 11. Jornada | 09.04.2021 | Marathón | - | Lobos UPNFM | 1:1 | ||||
| 12. Jornada | 17.04.2021 | Real Sociedad | - | Marathón | 1:1 | ||||
| 13. Jornada | 21.04.2021 | Marathón | - | Real de Minas | 3:2 | ||||
| 14. Jornada | 28.04.2021 | Olimpia | - | Marathón | 2:1 |
Honduras