| 1. Jornada | 07.02.2022 | River Plate | - | Montevideo Wanderers | 1:1 | ||||
| 2. Jornada | 12.02.2022 | Plaza Colonia | - | River Plate | 0:1 |  |
|||
| 3. Jornada | 19.02.2022 | River Plate | - | Boston River | 1:2 | ||||
| 5. Jornada | 05.03.2022 | River Plate | - | Cerro Largo | 1:1 | ||||
| 6. Jornada | 20.03.2022 | River Plate | - | Fénix | 3:1 | ||||
| 7. Jornada | 03.04.2022 | Defensor Sporting | - | River Plate | 3:2 | ||||
| 8. Jornada | 10.04.2022 | River Plate | - | Albion | 4:1 |  |
|||
| 13. Jornada | 22.05.2022 | Liverpool | - | River Plate | 2:1 |
Uruguay