| 1. Jornada | 02.06.2021 | Albion | - | CA Cerro | 1:2 |  |
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| 2. Jornada | 11.06.2021 | CA Cerro | - | Defensor Sporting | 0:0 | ||||
| 3. Jornada | 17.06.2021 | Central Español | - | CA Cerro | 3:2 |  |
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| 4. Jornada | 25.06.2021 | CA Cerro | - | Atenas | 1:1 | |
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| 5. Jornada | 01.07.2021 | Racing | - | CA Cerro | 0:0 | |
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| 6. Jornada | 08.07.2021 | CA Cerro | - | Villa Teresa | 1:1 | ||||
| 7. Jornada | 15.07.2021 | Juventud de Las Piedras | - | CA Cerro | 3:1 | |
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| 8. Jornada | 21.07.2021 | CA Cerro | - | Uruguay Montevideo | 0:1 | ||||
| 9. Jornada | 31.07.2021 | Rampla Juniors | - | CA Cerro | 0:1 | ||||
| 10. Jornada | 06.08.2021 | CA Cerro | - | Danubio | 1:1 | ||||
| 11. Jornada | 12.08.2021 | Rocha | - | CA Cerro | 1:3 | |
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| 14. Jornada | 29.09.2021 | CA Cerro | - | Central Español | 0:0 | ||||
| 15. Jornada | 04.10.2021 | Atenas | - | CA Cerro | 1:2 | ||||
| 16. Jornada | 14.10.2021 | CA Cerro | - | Racing | 1:0 | ||||
| 18. Jornada | 29.10.2021 | CA Cerro | - | Juventud de Las Piedras | 2:1 | ||||
| 22. Jornada | 24.11.2021 | CA Cerro | - | Rocha | 3:0 |
Uruguay