| 5. Jornada | 25.09.2021 | Gudja United | - | Valletta FC | 2:0 | ||||
| 6. Jornada | 16.10.2021 | Birkirkara FC | - | Gudja United | 2:0 | ||||
| 7. Jornada | 23.10.2021 | Gudja United | - | Hamrun Spartans | 1:3 |  |
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| 8. Jornada | 31.10.2021 | Balzan FC | - | Gudja United | 1:0 | ||||
| 9. Jornada | 20.11.2021 | Gudja United | - | Floriana FC | 0:1 | ||||
| 10. Jornada | 28.11.2021 | Gżira United | - | Gudja United | 3:2 |  |
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| 11. Jornada | 04.12.2021 | Mosta FC | - | Gudja United | 0:3 | ||||
| 12. Jornada | 13.12.2021 | Sirens FC | - | Gudja United | 0:0 | ||||
| 13. Jornada | 19.12.2021 | Gudja United | - | Hibernians FC | 1:2 | ||||
| 14. Jornada | 19.01.2022 | St. Luċija FC | - | Gudja United | 0:3 | |
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| 15. Jornada | 22.01.2022 | Gudja United | - | Sliema Wanderers | 1:0 | ||||
| 16. Jornada | 30.01.2022 | Valletta FC | - | Gudja United | 1:3 | ||||
| 17. Jornada | 06.02.2022 | Gudja United | - | Birkirkara FC | 0:1 | ||||
| 18. Jornada | 13.02.2022 | Hamrun Spartans | - | Gudja United | 0:1 | ||||
| 19. Jornada | 19.02.2022 | Gudja United | - | Balzan FC | 1:0 | |
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| 20. Jornada | 26.02.2022 | Floriana FC | - | Gudja United | 2:0 | |
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| 21. Jornada | 05.03.2022 | Gudja United | - | Gżira United | 1:2 | ||||
| 22. Jornada | 12.03.2022 | Gudja United | - | Mosta FC | 1:0 |
Malta