| 21. Jornada | 28.02.2022 | FK Pelister | - | FK Renova | 1:1 |  |
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| 22. Jornada | 09.03.2022 | FK Renova | - | KF Shkupi | 0:0 | ||||
| 23. Jornada | 14.03.2022 | FK Renova | - | FK Pelister | 0:0 | ||||
| 24. Jornada | 19.03.2022 | FK Renova | - | FK Rabotnički | 2:1 | ||||
| 25. Jornada | 03.04.2022 | FK Bregalnica Štip | - | FK Renova | 2:2 | ||||
| 26. Jornada | 06.04.2022 | FK Renova | - | Makedonija GP | 0:1 | ||||
| 28. Jornada | 17.04.2022 | FK Renova | - | FK AP Brera Strumica | 0:1 | ||||
| 32. Jornada | 08.05.2022 | FK Renova | - | FK Skopje | 2:0 | ||||
| 33. Jornada | 15.05.2022 | FK Borec | - | FK Renova | 1:5 |
Macedonia del Norte