| 1. Jornada | 18.07.2021 | Guaraní | - | Sol de América | 3:0 | ||||
| 2. Jornada | 25.07.2021 | Club Nacional | - | Guaraní | 1:1 | ||||
| 3. Jornada | 01.08.2021 | Guaraní | - | 12 de Octubre de Itauguá | 4:1 |  |
|||
| 4. Jornada | 07.08.2021 | Guaraní | - | Club Olimpia | 3:1 | ||||
| 5. Jornada | 15.08.2021 | Sportivo Luqueño | - | Guaraní | 1:4 | ||||
| 6. Jornada | 24.08.2021 | Guaraní | - | Libertad | 2:2 | ||||
| 7. Jornada | 30.08.2021 | River Plate | - | Guaraní | 1:5 | ||||
| 8. Jornada | 12.09.2021 | Guaraní | - | Guaireña FC | 3:0 | ||||
| 9. Jornada | 19.09.2021 | Cerro Porteño | - | Guaraní | 0:0 |  |
|||
| 10. Jornada | 28.09.2021 | Sol de América | - | Guaraní | 2:1 | |
|||
| 11. Jornada | 03.10.2021 | Guaraní | - | Club Nacional | 1:1 | ||||
| 13. Jornada | 24.10.2021 | Club Olimpia | - | Guaraní | 1:3 | ||||
| 14. Jornada | 31.10.2021 | Guaraní | - | Sportivo Luqueño | 2:1 | ||||
| 15. Jornada | 07.11.2021 | Libertad | - | Guaraní | 2:0 | ||||
| 16. Jornada | 20.11.2021 | Guaraní | - | River Plate | 2:1 | ||||
| 17. Jornada | 28.11.2021 | Guaireña FC | - | Guaraní | 1:1 | ||||
| 18. Jornada | 05.12.2021 | Guaraní | - | Cerro Porteño | 2:2 | |
Paraguay