| 10. Jornada | 25.09.2021 | Puebla FC | - | Cruz Azul | 1:1 | ||||
| 11. Jornada | 29.09.2021 | Atlas Guadalajara | - | Puebla FC | 0:1 | ||||
| 13. Jornada | 16.10.2021 | Club Necaxa | - | Puebla FC | 0:1 | ||||
| 14. Jornada | 20.10.2021 | Puebla FC | - | Mazatlán FC | 2:0 |  |
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| 15. Jornada | 24.10.2021 | Puebla FC | - | Club León | 0:1 | ||||
| 16. Jornada | 30.10.2021 | FC Juárez | - | Puebla FC | 0:2 | ||||
| 17. Jornada | 06.11.2021 | Puebla FC | - | Deportivo Toluca | 1:0 | |
México