| 8. Jornada | 26.09.2021 | Veraguas Club Deportivo | - | Sporting San Miguelito | 2:0 | ||||
| 9. Jornada | 03.10.2021 | Sporting San Miguelito | - | Herrera FC | 1:1 |  |
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| 11. Jornada | 17.10.2021 | Atlético Chiriquí | - | Sporting San Miguelito | 1:1 | ||||
| 12. Jornada | 23.10.2021 | Alianza | - | Sporting San Miguelito | 1:0 | ||||
| 13. Jornada | 31.10.2021 | Sporting San Miguelito | - | Plaza Amador | 1:1 | ||||
| 15. Jornada | 13.11.2021 | Deportivo del Este | - | Sporting San Miguelito | 1:0 | ||||
| 16. Jornada | 20.11.2021 | Sporting San Miguelito | - | Árabe Unido | 1:2 |
Panamá