| 17. Jornada | 17.10.2022 | Club Nacional | - | Guaraní | 2:0 | ||||
| 18. Jornada | 23.10.2022 | Guaraní | - | Cerro Porteño | 1:2 | ||||
| 19. Jornada | 27.10.2022 | Guaraní | - | Libertad | 1:2 | ||||
| 20. Jornada | 30.10.2022 | Guaireña FC | - | Guaraní | 1:0 | ||||
| 21. Jornada | 06.11.2022 | Guaraní | - | Tacuary | 2:1 |  |
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| 22. Jornada | 13.11.2022 | Sportivo Ameliano | - | Guaraní | 4:2 |
Paraguay