| 1. Jornada | 18.09.2021 | Atlas Guadalajara [] | - | Deportivo Guadalajara [] | 4:2 |  |
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| 2. Jornada | 25.09.2021 | Santos Laguna [] | - | Atlas Guadalajara [] | 2:0 | ||||
| 5. Jornada | 16.10.2021 | Atlas Guadalajara [] | - | Club Necaxa [] | 1:2 | ||||
| 6. Jornada | 23.10.2021 | Atlas Guadalajara [] | - | Club León [] | 2:0 | ||||
| 8. Jornada | 06.11.2021 | Deportivo Guadalajara [] | - | Atlas Guadalajara [] | 3:0 | ||||
| 9. Jornada | 13.11.2021 | Atlas Guadalajara [] | - | UANL Tigres [] | 3:2 | |
México