| 1. Jornada | 25.07.2010 | Deportivo Guadalajara | - | Puebla FC | 0:0 |  |
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| 2. Jornada | 01.08.2010 | Puebla FC | - | Club San Luis | 2:1 | ||||
| 4. Jornada | 15.08.2010 | Puebla FC | - | Atlante | 1:1 | |
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| 5. Jornada | 22.08.2010 | Pumas UNAM | - | Puebla FC | 4:1 | ||||
| 6. Jornada | 29.08.2010 | Puebla FC | - | CF Pachuca | 3:1 |  |
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| 8. Jornada | 19.09.2010 | Puebla FC | - | UANL Tigres | 1:3 | ||||
| 9. Jornada | 26.09.2010 | Atlas Guadalajara | - | Puebla FC | 1:0 |
Uruguay