| 1. Jornada | 31.01.2010 | Sportivo Luqueño | - | Sport Colombia | 2:3 |  |
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| 2. Jornada | 07.02.2010 | Sport Colombia | - | Sportivo Trinidense | 0:0 | ||||
| 3. Jornada | 13.02.2010 | Club Nacional | - | Sport Colombia | 1:2 | ||||
| 4. Jornada | 17.02.2010 | Sport Colombia | - | 3 de Febrero | 2:3 | ||||
| 5. Jornada | 21.02.2010 | Sol de América | - | Sport Colombia | 1:2 | |
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| 7. Jornada | 07.03.2010 | Sport Colombia | - | Club Olimpia | 0:4 | ||||
| 8. Jornada | 13.03.2010 | Cerro Porteño | - | Sport Colombia | 4:1 | ||||
| 9. Jornada | 17.03.2010 | Sport Colombia | - | Guaraní | 1:3 | ||||
| 10. Jornada | 21.03.2010 | Club Rubio Ñu | - | Sport Colombia | 2:1 | ||||
| 13. Jornada | 10.04.2010 | Sportivo Trinidense | - | Sport Colombia | 1:0 | ||||
| 16. Jornada | 25.04.2010 | Sport Colombia | - | Sol de América | 2:2 | |
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| 17. Jornada | 03.05.2010 | Sport Colombia | - | Libertad | 0:1 | |
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| 18. Jornada | 09.05.2010 | Club Olimpia | - | Sport Colombia | 2:1 | ||||
| 19. Jornada | 12.05.2010 | Sport Colombia | - | Cerro Porteño | 1:1 | ||||
| 20. Jornada | 16.05.2010 | Guaraní | - | Sport Colombia | 1:0 | ||||
| 21. Jornada | 23.05.2010 | Sport Colombia | - | Club Rubio Ñu | 2:4 | |
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| 22. Jornada | 28.05.2010 | Tacuary | - | Sport Colombia | 2:2 |
Paraguay