| 2. Jornada | 13.01.2018 | Monarcas Morelia | - | Puebla FC | 1:0 | ||||
| 3. Jornada | 20.01.2018 | Puebla FC | - | CD Veracruz | 2:0 | ||||
| 4. Jornada | 27.01.2018 | Club Tijuana | - | Puebla FC | 2:0 | ||||
| 5. Jornada | 03.02.2018 | Puebla FC | - | Deportivo Guadalajara | 2:0 |  |
|||
| 7. Jornada | 15.02.2018 | Puebla FC | - | Deportivo Toluca | 2:0 | ||||
| 8. Jornada | 18.02.2018 | Cruz Azul | - | Puebla FC | 1:1 | ||||
| 9. Jornada | 24.02.2018 | Puebla FC | - | Club Necaxa | 1:1 | ||||
| 10. Jornada | 04.03.2018 | CF Monterrey | - | Puebla FC | 1:3 | ||||
| 12. Jornada | 17.03.2018 | Puebla FC | - | Santos Laguna | 0:1 | ||||
| 13. Jornada | 01.04.2018 | Gallos Blancos | - | Puebla FC | 2:1 | ||||
| 14. Jornada | 07.04.2018 | Puebla FC | - | CF Pachuca | 2:6 |  |
|||
| 15. Jornada | 15.04.2018 | Pumas UNAM | - | Puebla FC | 4:2 | ||||
| 16. Jornada | 21.04.2018 | Puebla FC | - | CF América | 3:1 | |
 |
||
| 17. Jornada | 29.04.2018 | Lobos BUAP | - | Puebla FC | 0:1 |
Bolivia
