| 4. Jornada | 11.04.2021 | Jorge Wilstermann | - | The Strongest | 0:3 | ||||
| 5. Jornada | 26.04.2021 | Independiente Petrolero | - | Jorge Wilstermann | 5:4 |  |
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| 6. Jornada | 03.05.2021 | Atlético Palmaflor | - | Jorge Wilstermann | 3:1 |  |
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| 11. Jornada | 27.07.2021 | Jorge Wilstermann | - | Blooming | 2:1 | ||||
| 12. Jornada | 01.08.2021 | Bolívar | - | Jorge Wilstermann | 4:0 | ||||
| 13. Jornada | 06.08.2021 | Jorge Wilstermann | - | Club Aurora | 2:1 | ||||
| 14. Jornada | 08.08.2021 | Real Tomayapo | - | Jorge Wilstermann | 1:2 | ||||
| 17. Jornada | 22.08.2021 | Nacional Potosí | - | Jorge Wilstermann | 0:1 | ||||
| 22. Jornada | 20.10.2021 | Always Ready | - | Jorge Wilstermann | 0:0 | ||||
| 23. Jornada | 23.10.2021 | Jorge Wilstermann | - | Royal Pari | 4:1 | ||||
| 24. Jornada | 27.10.2021 | Real Potosí | - | Jorge Wilstermann | 2:2 |  |
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| 25. Jornada | 30.10.2021 | Jorge Wilstermann | - | CD Guabirá | 2:1 | ||||
| 26. Jornada | 22.11.2021 | Blooming | - | Jorge Wilstermann | 2:2 | ||||
| 27. Jornada | 28.11.2021 | Jorge Wilstermann | - | Bolívar | 1:0 | ||||
| 28. Jornada | 02.12.2021 | Club Aurora | - | Jorge Wilstermann | 1:1 | ||||
| 29. Jornada | 07.12.2021 | Jorge Wilstermann | - | Real Tomayapo | 3:0 | |
Estados Unidos
Bolivia