| 1. Jornada | 18.07.2021 | Luki-Energiya Velikiye Luki | - | Zenit 2 | 3:3 | ||||
| 3. Jornada | 01.08.2021 | Zenit 2 | - | Zvezda St. Petersburg | 2:1 | ||||
| 4. Jornada | 07.08.2021 | Dinamo St. Petersburg | - | Zenit 2 | 2:0 | ||||
| 5. Jornada | 15.08.2021 | Zenit 2 | - | FK Kairat Moskva | 1:2 | ||||
| 6. Jornada | 21.08.2021 | FK Krasava | - | Zenit 2 | 6:0 | ||||
| 7. Jornada | 28.08.2021 | Zenit 2 | - | FK Chita | 4:0 |  |
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| 8. Jornada | 04.09.2021 | FK Tver | - | Zenit 2 | 2:2 | ||||
| 9. Jornada | 10.09.2021 | Zenit 2 | - | FK Leningradets | 1:1 | |
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| 11. Jornada | 18.09.2021 | Zenit 2 | - | Baltika Kaliningrad 2 | 2:1 | |
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| 14. Jornada | 04.10.2021 | Zenit 2 | - | Dinamo St. Petersburg | 1:2 | ||||
| 15. Jornada | 10.10.2021 | FK Kairat Moskva | - | Zenit 2 | 3:0 | ||||
| 16. Jornada | 14.10.2021 | Zenit 2 | - | FK Krasava | 1:0 | ||||
| 18. Jornada | 25.10.2021 | Zenit 2 | - | FK Tver | 1:1 | ||||
| 21. Jornada | 10.11.2021 | Baltika Kaliningrad 2 | - | Zenit 2 | 2:1 | ||||
| 22. Jornada | 14.11.2021 | Zenit 2 | - | Luki-Energiya Velikiye Luki | 5:3 |
Rusia