| 5. Jornada | 13.03.2022 | Nacional | - | Montevideo City Torque | 1:1 | ||||
| 6. Jornada | 20.03.2022 | Montevideo Wanderers | - | Nacional | 2:2 |  |
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| 7. Jornada | 02.04.2022 | Nacional | - | Plaza Colonia | 1:0 | ||||
| 8. Jornada | 10.04.2022 | Boston River | - | Nacional | 0:6 | |
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| 9. Jornada | 17.04.2022 | Nacional | - | River Plate | 1:1 | ||||
| 10. Jornada | 23.04.2022 | Cerro Largo | - | Nacional | 0:2 | |
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| 12. Jornada | 14.05.2022 | Defensor Sporting | - | Nacional | 0:2 | ||||
| 13. Jornada | 21.05.2022 | Nacional | - | Albion | 2:0 | |
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| 14. Jornada | 29.05.2022 | Nacional | - | Cerrito | 3:0 | ||||
| 15. Jornada | 05.06.2022 | Danubio | - | Nacional | 2:1 |
Colombia