| 21. Jornada | 30.12.2017 | Manchester United | - | Southampton | 0:0 | ||||
| 22. Jornada | 02.01.2018 | Southampton | - | Crystal Palace | 1:2 | ||||
| 23. Jornada | 13.01.2018 | Watford FC | - | Southampton | 2:2 |  |
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| 24. Jornada | 21.01.2018 | Southampton | - | Tottenham Hotspur | 1:1 | ||||
| 25. Jornada | 31.01.2018 | Southampton | - | Brighton & Hove Albion | 1:1 | ||||
| 26. Jornada | 03.02.2018 | West Bromwich Albion | - | Southampton | 2:3 | ||||
| 27. Jornada | 11.02.2018 | Southampton | - | Liverpool | 0:2 | ||||
| 28. Jornada | 24.02.2018 | Burnley FC | - | Southampton | 1:1 | ||||
| 29. Jornada | 03.03.2018 | Southampton | - | Stoke City | 0:0 | ||||
| 30. Jornada | 10.03.2018 | Newcastle United | - | Southampton | 3:0 | ||||
| 32. Jornada | 31.03.2018 | West Ham United | - | Southampton | 3:0 | ||||
| 33. Jornada | 08.04.2018 | Arsenal | - | Southampton | 3:2 | ||||
| 34. Jornada | 14.04.2018 | Southampton | - | Chelsea | 2:3 | ||||
| 35. Jornada | 19.04.2018 | Leicester City | - | Southampton | 0:0 | ||||
| 36. Jornada | 28.04.2018 | Southampton | - | Bournemouth | 2:1 | |
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| 37. Jornada | 05.05.2018 | Everton | - | Southampton | 1:1 | ||||
| 31. Jornada | 08.05.2018 | Swansea City | - | Southampton | 0:1 | ||||
| 38. Jornada | 13.05.2018 | Southampton | - | Manchester City | 0:1 |
Inglaterra