| 25. Jornada | 30.01.2022 | Union Saint-Gilloise | - | RSC Anderlecht | 1:0 | ||||
| 27. Jornada | 13.02.2022 | Union Saint-Gilloise | - | Sint-Truidense VV | 0:1 | ||||
| 28. Jornada | 19.02.2022 | Sporting Charleroi | - | Union Saint-Gilloise | 0:3 |  |
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| 29. Jornada | 26.02.2022 | Union Saint-Gilloise | - | KAS Eupen | 0:0 | ||||
| 31. Jornada | 11.03.2022 | Oud-Heverlee Leuven | - | Union Saint-Gilloise | 1:4 | ||||
| 32. Jornada | 18.03.2022 | Union Saint-Gilloise | - | KV Oostende | 1:1 | ||||
| 33. Jornada | 03.04.2022 | Standard Liège | - | Union Saint-Gilloise | 1:3 |
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