| 1. Jornada | 12.09.2021 | Boston River | - | Montevideo Wanderers | 1:3 | ||||
| 2. Jornada | 17.09.2021 | Rentistas | - | Boston River | 1:2 | ||||
| 3. Jornada | 26.09.2021 | Boston River | - | Peñarol | 2:5 | ||||
| 9. Jornada | 30.10.2021 | Boston River | - | River Plate | 1:2 | ||||
| 10. Jornada | 04.11.2021 | Cerro Largo | - | Boston River | 1:1 | ||||
| 11. Jornada | 08.11.2021 | Boston River | - | Progreso | 0:0 | ||||
| 13. Jornada | 22.11.2021 | Boston River | - | Plaza Colonia | 2:0 |  |
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| 15. Jornada | 04.12.2021 | Boston River | - | Deportivo Maldonado | 2:1 |
Uruguay