| 4. Jornada | 25.02.2022 | Boston River | - | Cerro Largo | 3:0 |  |
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| 5. Jornada | 12.03.2022 | Fénix | - | Boston River | 0:2 | ||||
| 6. Jornada | 21.03.2022 | Boston River | - | Defensor Sporting | 1:1 | ||||
| 7. Jornada | 02.04.2022 | Albion | - | Boston River | 1:2 | |
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| 8. Jornada | 10.04.2022 | Boston River | - | Nacional | 0:6 | ||||
| 9. Jornada | 15.04.2022 | Danubio | - | Boston River | 0:0 | ||||
| 10. Jornada | 24.04.2022 | Boston River | - | Deportivo Maldonado | 2:0 | |
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| 11. Jornada | 08.05.2022 | Rentistas | - | Boston River | 0:1 | ||||
| 12. Jornada | 16.05.2022 | Boston River | - | Liverpool | 2:3 | |
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| 14. Jornada | 28.05.2022 | Boston River | - | Montevideo City Torque | 3:1 |  |
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| 15. Jornada | 06.06.2022 | Montevideo Wanderers | - | Boston River | 1:2 | |
Uruguay