| 8. Jornada | 28.02.2010 | Puebla FC | - | Jaguares Chiapas | 3:3 | ||||
| 9. Jornada | 07.03.2010 | Pumas UNAM | - | Puebla FC | 4:1 | ||||
| 11. Jornada | 21.03.2010 | Santos Laguna | - | Puebla FC | 2:1 | ||||
| 12. Jornada | 29.03.2010 | Puebla FC | - | CF América | 2:1 | ||||
| 13. Jornada | 04.04.2010 | Monarcas Morelia | - | Puebla FC | 1:1 | ||||
| 14. Jornada | 11.04.2010 | Puebla FC | - | Indios Juárez | 1:2 | ||||
| 15. Jornada | 15.04.2010 | Atlas Guadalajara | - | Puebla FC | 0:2 |  |
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| 16. Jornada | 18.04.2010 | Puebla FC | - | Cruz Azul | 4:1 | ||||
| 17. Jornada | 25.04.2010 | Deportivo Toluca | - | Puebla FC | 2:1 | |
México