| 1. Jornada | 06.11.2021 | Olympiakos Piraeus II | - | PAOK Saloniki II | 3:1 | ||||
| 10. Jornada | 29.12.2021 | Olympiakos Piraeus II | - | Anagennisi Karditsa | 0:1 | ||||
| 11. Jornada | 19.01.2022 | Pierikos Katerini | - | Olympiakos Piraeus II | 1:2 | ||||
| 15. Jornada | 22.01.2022 | Almopos Arideas | - | Olympiakos Piraeus II | 3:0 | ||||
| 16. Jornada | 30.01.2022 | Olympiakos Piraeus II | - | Niki Volou FC | 2:0 | ||||
| 12. Jornada | 02.02.2022 | Olympiakos Piraeus II | - | Xanthi FC | 1:1 | ||||
| 17. Jornada | 05.02.2022 | Olympiacos Volou | - | Olympiakos Piraeus II | 2:3 | ||||
| 18. Jornada | 13.02.2022 | PAOK Saloniki II | - | Olympiakos Piraeus II | 1:0 |  |
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| 19. Jornada | 16.02.2022 | Olympiakos Piraeus II | - | AO Trikala | 2:0 | ||||
| 21. Jornada | 26.02.2022 | Olympiakos Piraeus II | - | Apollon Lárissa | 0:1 | |
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| 29. Jornada | 06.04.2022 | Xanthi FC | - | Olympiakos Piraeus II | 2:1 | ||||
| 33. Jornada | 27.04.2022 | Niki Volou FC | - | Olympiakos Piraeus II | 0:1 | ||||
| 34. Jornada | 01.05.2022 | Olympiakos Piraeus II | - | Olympiacos Volou | 3:2 | |
Grecia