| 18. Jornada | 01.09.2021 | San Luis | - | Puerto Montt | 0:1 | ||||
| 21. Jornada | 22.09.2021 | Fernández Vial | - | San Luis | 2:2 | ||||
| 22. Jornada | 26.09.2021 | Deportes Copiapó | - | San Luis | 4:1 |  |
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| 24. Jornada | 09.10.2021 | San Marcos | - | San Luis | 1:2 |  |
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| 25. Jornada | 12.10.2021 | San Luis | - | Santa Cruz | 0:0 | ||||
| 26. Jornada | 21.10.2021 | San Luis | - | Santiago Morning | 2:2 | ||||
| 29. Jornada | 06.11.2021 | CD Magallanes | - | San Luis | 3:3 |
Chile