| 2. Jornada | 22.02.2022 | Deportes Temuco | - | Santiago Wanderers | 1:0 | ||||
| 3. Jornada | 02.03.2022 | Santiago Wanderers | - | Santiago Morning | 2:2 | ||||
| 4. Jornada | 10.03.2022 | San Luis | - | Santiago Wanderers | 1:1 |  |
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| 6. Jornada | 22.03.2022 | Fernández Vial | - | Santiago Wanderers | 0:0 | |
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| 7. Jornada | 03.04.2022 | Santiago Wanderers | - | CD Magallanes | 0:2 | ||||
| 13. Jornada | 07.05.2022 | Santiago Wanderers | - | Barnechea | 1:3 |
Chile