| 9. Jornada | 18.09.2021 | Club León [Sub 20] | - | FC Juárez [Sub 20] | 2:0 |  |
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| 10. Jornada | 25.09.2021 | Atlas Guadalajara [Sub 20] | - | Club León [Sub 20] | 2:1 | ||||
| 12. Jornada | 02.10.2021 | Club León [Sub 20] | - | Atlético San Luis [Sub 20] | 2:0 | ||||
| 17. Jornada | 06.11.2021 | Club León [Sub 20] | - | Club Necaxa [Sub 20] | 3:1 |
México