| 14. Jornada | 21.11.2021 | FK Borec | - | FK Renova | 1:4 |  |
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| 15. Jornada | 27.11.2021 | FK Renova | - | FK AP Brera Strumica | 1:2 | ||||
| 16. Jornada | 04.12.2021 | FK Rabotnički | - | FK Renova | 0:0 | |
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| 19. Jornada | 12.02.2022 | FK Bregalnica Štip | - | FK Renova | 1:2 | ||||
| 20. Jornada | 20.02.2022 | FK Renova | - | Makedonija GP | 0:1 | ||||
| 23. Jornada | 14.03.2022 | FK Renova | - | FK Pelister | 0:0 | ||||
| 27. Jornada | 10.04.2022 | KF Shkëndija 79 | - | FK Renova | 1:1 | ||||
| 30. Jornada | 01.05.2022 | FK Renova | - | FC Struga | 1:1 | ||||
| 33. Jornada | 15.05.2022 | FK Borec | - | FK Renova | 1:5 |
Macedonia del Norte