| 1. Jornada | 20.01.2008 | CF América | - | Puebla FC | 0:0 | ||||
| 2. Jornada | 27.01.2008 | Puebla FC | - | CF Monterrey | 1:1 |  |
 |
||
| 3. Jornada | 03.02.2008 | Puebla FC | - | Club Necaxa | 1:1 | |
|||
| 6. Jornada | 17.02.2008 | UAG Tecos | - | Puebla FC | 3:2 | ||||
| 7. Jornada | 24.02.2008 | Puebla FC | - | Monarcas Morelia | 4:0 | |
|||
| 8. Jornada | 02.03.2008 | Atlas Guadalajara | - | Puebla FC | 2:1 | ||||
| 9. Jornada | 09.03.2008 | Puebla FC | - | Santos Laguna | 3:3 | |
|||
| 10. Jornada | 16.03.2008 | UANL Tigres | - | Puebla FC | 0:3 | |
|||
| 11. Jornada | 23.03.2008 | Puebla FC | - | Club San Luis | 1:2 | ||||
| 12. Jornada | 30.03.2008 | Cruz Azul | - | Puebla FC | 2:0 | ||||
| 13. Jornada | 06.04.2008 | Puebla FC | - | Deportivo Toluca | 1:2 | |
|
||
| 14. Jornada | 12.04.2008 | Veracruz (old) | - | Puebla FC | 0:2 | |
|||
| 15. Jornada | 20.04.2008 | Puebla FC | - | CF Pachuca | 5:2 | ||||
| 16. Jornada | 27.04.2008 | Deportivo Guadalajara | - | Puebla FC | 4:0 | ||||
| 17. Jornada | 04.05.2008 | Puebla FC | - | Atlante | 2:2 |
Uruguay