| 1. Jornada | 27.07.2008 | Puebla FC | - | CF Monterrey | 2:2 |  |
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| 2. Jornada | 03.08.2008 | Club Necaxa | - | Puebla FC | 0:0 | ||||
| 3. Jornada | 10.08.2008 | Puebla FC | - | Santos Laguna | 0:0 | |
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| 4. Jornada | 17.08.2008 | Deportivo Toluca | - | Puebla FC | 3:1 | ||||
| 5. Jornada | 24.08.2008 | Puebla FC | - | Monarcas Morelia | 2:0 | |
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| 6. Jornada | 28.08.2008 | CF Pachuca | - | Puebla FC | 2:0 | ||||
| 7. Jornada | 31.08.2008 | Puebla FC | - | Jaguares Chiapas | 1:1 | ||||
| 8. Jornada | 14.09.2008 | Atlas Guadalajara | - | Puebla FC | 2:0 | ||||
| 10. Jornada | 28.09.2008 | Club San Luis | - | Puebla FC | 1:1 | ||||
| 11. Jornada | 05.10.2008 | Puebla FC | - | Atlante | 0:2 | ||||
| 12. Jornada | 12.10.2008 | CF América | - | Puebla FC | 1:1 | ||||
| 16. Jornada | 09.11.2008 | Puebla FC | - | Deportivo Guadalajara | 2:1 | |
Uruguay