| 1. Jornada | 03.06.2021 | Defensor Sporting | - | Rocha | 2:1 | ||||
| 2. Jornada | 11.06.2021 | CA Cerro | - | Defensor Sporting | 0:0 | ||||
| 5. Jornada | 01.07.2021 | Atenas | - | Defensor Sporting | 2:0 | ||||
| 12. Jornada | 16.09.2021 | Rocha | - | Defensor Sporting | 1:2 | ||||
| 13. Jornada | 23.09.2021 | Defensor Sporting | - | CA Cerro | 2:0 | ||||
| 14. Jornada | 30.09.2021 | Defensor Sporting | - | Albion | 0:1 | ||||
| 15. Jornada | 05.10.2021 | Central Español | - | Defensor Sporting | 1:0 | ||||
| 16. Jornada | 12.10.2021 | Defensor Sporting | - | Atenas | 1:1 |  |
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| 17. Jornada | 20.10.2021 | Racing | - | Defensor Sporting | 0:1 | ||||
| 18. Jornada | 29.10.2021 | Defensor Sporting | - | Villa Teresa | 1:2 | ||||
| 19. Jornada | 02.11.2021 | Juventud de Las Piedras | - | Defensor Sporting | 3:3 |  |
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| 20. Jornada | 10.11.2021 | Defensor Sporting | - | Uruguay Montevideo | 2:0 | ||||
| 21. Jornada | 18.11.2021 | Rampla Juniors | - | Defensor Sporting | 0:5 | |
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| 22. Jornada | 24.11.2021 | Defensor Sporting | - | Danubio | 0:1 |
Uruguay