| 8. Jornada | 02.03.2016 | Deportivo Capiatá | - | River Plate | 1:1 | ||||
| 12. Jornada | 01.04.2016 | Cerro Porteño | - | River Plate | 4:0 |  |
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| 13. Jornada | 06.04.2016 | River Plate | - | Sol de América | 1:1 | |
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| 14. Jornada | 11.04.2016 | Sportivo Luqueño | - | River Plate | 2:0 | ||||
| 15. Jornada | 17.04.2016 | River Plate | - | Libertad | 1:3 | |
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| 17. Jornada | 25.04.2016 | River Plate | - | Club Nacional | 1:3 | |
Uruguay