| 1. Jornada | 25.07.2010 | Universitario de Sucre | - | Club San José | 2:2 |  |
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| 2. Jornada | 01.08.2010 | Club San José | - | Blooming | 2:0 | ||||
| 3. Jornada | 08.08.2010 | Jorge Wilstermann | - | Club San José | 1:3 | ||||
| 4. Jornada | 15.08.2010 | Club San José | - | The Strongest | 3:2 | ||||
| 10. Jornada | 18.09.2010 | Club San José | - | Real Mamoré | 1:0 | ||||
| 14. Jornada | 10.10.2010 | Club San José | - | Jorge Wilstermann | 2:0 | ||||
| 15. Jornada | 17.10.2010 | The Strongest | - | Club San José | 1:2 | ||||
| 13. Jornada | 28.10.2010 | Blooming | - | Club San José | 2:2 | |
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| 17. Jornada | 04.11.2010 | Real Potosí | - | Club San José | 1:3 | |
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| 19. Jornada | 07.11.2010 | Club Aurora | - | Club San José | 4:1 | ||||
| 20. Jornada | 14.11.2010 | Club San José | - | Bolívar | 0:1 |  |
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| 22. Jornada | 28.11.2010 | Club San José | - | La Paz FC | 1:0 |
Bolivia