| 1. Jornada | 09.01.2022 | Pumas UNAM [Sub 20] | - | Deportivo Toluca [Sub 20] | 1:1 | ||||
| 2. Jornada | 14.01.2022 | Gallos Blancos [Sub 20] | - | Pumas UNAM [Sub 20] | 0:1 |  |
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| 14. Jornada | 27.01.2022 | Pumas UNAM [Sub 20] | - | CF Monterrey [Sub 20] | 4:0 | |
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| 10. Jornada | 12.03.2022 | Cruz Azul [Sub 20] | - | Pumas UNAM [Sub 20] | 1:0 | ||||
| 11. Jornada | 19.03.2022 | Pumas UNAM [Sub 20] | - | Club Necaxa [Sub 20] | 1:2 | |
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| 9. Jornada | 27.03.2022 | Pumas UNAM [Sub 20] | - | Mazatlán FC [Sub 20] | 3:0 | ||||
| 13. Jornada | 08.04.2022 | Puebla FC [Sub 20] | - | Pumas UNAM [Sub 20] | 2:2 | |
México