| 20. Jornada | 20.02.2022 | GFK Tikvesh | - | FK Pelister | 1:0 | ||||
| 21. Jornada | 28.02.2022 | FK Pelister | - | FK Renova | 1:1 | ||||
| 22. Jornada | 09.03.2022 | FK Bregalnica Štip | - | FK Pelister | 2:1 | ||||
| 23. Jornada | 14.03.2022 | FK Renova | - | FK Pelister | 0:0 |  |
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| 24. Jornada | 19.03.2022 | FK Pelister | - | FK Bregalnica Štip | 2:0 | ||||
| 25. Jornada | 03.04.2022 | Makedonija GP | - | FK Pelister | 2:0 | ||||
| 26. Jornada | 06.04.2022 | FK Pelister | - | KF Shkëndija 79 | 0:2 | ||||
| 27. Jornada | 10.04.2022 | FK AP Brera Strumica | - | FK Pelister | 2:0 | ||||
| 28. Jornada | 16.04.2022 | FK Pelister | - | KF Shkupi | 0:1 | ||||
| 29. Jornada | 23.04.2022 | FC Struga | - | FK Pelister | 4:0 | ||||
| 30. Jornada | 01.05.2022 | FK Pelister | - | GFK Tikvesh | 1:1 | ||||
| 31. Jornada | 04.05.2022 | FK Skopje | - | FK Pelister | 4:2 | ||||
| 32. Jornada | 08.05.2022 | FK Pelister | - | FK Borec | 2:1 |
Macedonia del Norte