| 1. Jornada | 06.11.2021 | Olympiakos Piraeus II | - | PAOK Saloniki II | 3:1 | ||||
| 3. Jornada | 20.11.2021 | Olympiakos Piraeus II | - | AE Lárissa | 1:0 | ||||
| 2. Jornada | 08.12.2021 | AO Trikala | - | Olympiakos Piraeus II | 0:0 | ||||
| 7. Jornada | 12.12.2021 | AEP Iraklis FC | - | Olympiakos Piraeus II | 0:0 | ||||
| 13. Jornada | 12.01.2022 | Thesprotos | - | Olympiakos Piraeus II | 2:1 | ||||
| 14. Jornada | 15.01.2022 | Olympiakos Piraeus II | - | AO Kavala | 2:2 | ||||
| 11. Jornada | 19.01.2022 | Pierikos Katerini | - | Olympiakos Piraeus II | 1:2 |  |
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| 15. Jornada | 22.01.2022 | Almopos Arideas | - | Olympiakos Piraeus II | 3:0 | ||||
| 12. Jornada | 02.02.2022 | Olympiakos Piraeus II | - | Xanthi FC | 1:1 | ||||
| 17. Jornada | 05.02.2022 | Olympiacos Volou | - | Olympiakos Piraeus II | 2:3 | ||||
| 32. Jornada | 16.04.2022 | Olympiakos Piraeus II | - | Almopos Arideas | 2:1 | ||||
| 33. Jornada | 27.04.2022 | Niki Volou FC | - | Olympiakos Piraeus II | 0:1 | ||||
| 34. Jornada | 01.05.2022 | Olympiakos Piraeus II | - | Olympiacos Volou | 3:2 |
Grecia