| 1. Jornada | 07.11.2021 | AO Episkopi | - | AE Karaiskakis | 0:1 |  |
|||
| 2. Jornada | 13.11.2021 | AE Karaiskakis | - | AE Kifisias | 0:2 | ||||
| 3. Jornada | 20.11.2021 | AEK Athen II | - | AE Karaiskakis | 2:1 | ||||
| 4. Jornada | 24.11.2021 | AE Karaiskakis | - | PS Kalamata | 0:1 | ||||
| 5. Jornada | 27.11.2021 | Panathinaikos II | - | AE Karaiskakis | 2:2 | ||||
| 7. Jornada | 11.12.2021 | AE Karaiskakis | - | Ergotelis | 3:2 | |
|||
| 8. Jornada | 15.12.2021 | Asteras Vlachioti | - | AE Karaiskakis | 1:1 | ||||
| 9. Jornada | 19.12.2021 | AE Karaiskakis | - | Diagoras FC | 0:0 |  |
|||
| 10. Jornada | 29.12.2021 | PAE Chania | - | AE Karaiskakis | 4:0 | ||||
| 14. Jornada | 16.01.2022 | AO Egaleo | - | AE Karaiskakis | 1:0 | ||||
| 15. Jornada | 23.01.2022 | AE Karaiskakis | - | Irodotos | 2:1 | |
|||
| 11. Jornada | 26.01.2022 | AE Karaiskakis | - | APS Zakynthos | 0:2 |
Grecia