| 1. Jornada | 08.08.2021 | FK AP Brera Strumica | - | FC Struga | 1:1 | ||||
| 3. Jornada | 18.08.2021 | GFK Tikvesh | - | FK AP Brera Strumica | 0:2 | ||||
| 4. Jornada | 22.08.2021 | FK AP Brera Strumica | - | FK Renova | 2:1 |  |
 |
||
| 5. Jornada | 28.08.2021 | FK Bregalnica Štip | - | FK AP Brera Strumica | 3:2 | |
|||
| 14. Jornada | 21.11.2021 | FK AP Brera Strumica | - | GFK Tikvesh | 3:2 | ||||
| 15. Jornada | 27.11.2021 | FK Renova | - | FK AP Brera Strumica | 1:2 | |
|||
| 16. Jornada | 05.12.2021 | FK AP Brera Strumica | - | FK Bregalnica Štip | 0:0 | ||||
| 17. Jornada | 08.12.2021 | Makedonija GP | - | FK AP Brera Strumica | 4:1 | |
|||
| 18. Jornada | 12.12.2021 | FK AP Brera Strumica | - | FK Pelister | 1:0 |
Macedonia del Norte