| 2. Jornada | 16.01.2022 | Club Tijuana | - | Club León | 1:1 | ||||
| 3. Jornada | 23.01.2022 | Club León | - | CF Pachuca | 2:1 |  |
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| 4. Jornada | 08.02.2022 | Club León | - | Cruz Azul | 0:1 | ||||
| 5. Jornada | 13.02.2022 | Pumas UNAM | - | Club León | 2:1 | ||||
| 6. Jornada | 20.02.2022 | Club León | - | Deportivo Guadalajara | 2:1 | ||||
| 7. Jornada | 26.02.2022 | Club Necaxa | - | Club León | 0:1 | ||||
| 8. Jornada | 02.03.2022 | Club León | - | CF Monterrey | 0:0 | ||||
| 9. Jornada | 05.03.2022 | FC Juárez | - | Club León | 0:1 | ||||
| 10. Jornada | 13.03.2022 | Club León | - | UANL Tigres | 0:3 | ||||
| 11. Jornada | 21.03.2022 | Mazatlán FC | - | Club León | 1:2 | ||||
| 12. Jornada | 04.04.2022 | Club León | - | Gallos Blancos | 1:1 | ||||
| 13. Jornada | 10.04.2022 | Atlético San Luis | - | Club León | 2:0 | ||||
| 14. Jornada | 17.04.2022 | Club León | - | Puebla FC | 0:1 | ||||
| 15. Jornada | 21.04.2022 | CF América | - | Club León | 2:0 | ||||
| 16. Jornada | 25.04.2022 | Santos Laguna | - | Club León | 1:1 | ||||
| 17. Jornada | 02.05.2022 | Club León | - | Deportivo Toluca | 4:4 |
Colombia