| 1. Jornada | 25.07.2021 | MFK Zemplín Michalovce | - | FC DAC 1904 | 4:1 | ||||
| 4. Jornada | 14.08.2021 | Slovan Bratislava | - | MFK Zemplín Michalovce | 3:1 | ||||
| 12. Jornada | 24.10.2021 | FC DAC 1904 | - | MFK Zemplín Michalovce | 1:0 | ||||
| 14. Jornada | 05.11.2021 | AS Trenčín | - | MFK Zemplín Michalovce | 4:2 | ||||
| 20. Jornada | 11.02.2022 | MFK Zemplín Michalovce | - | ŠKF Sereď | 0:1 | ||||
| 21. Jornada | 19.02.2022 | MŠK Žilina | - | MFK Zemplín Michalovce | 2:1 | ||||
| 22. Jornada | 26.02.2022 | MFK Zemplín Michalovce | - | FK Senica | 0:1 |
Moldavia
Ucrania