| 1. Jornada | 16.01.2021 | Danubio | - | Cerro Largo | 0:3 |  |
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| 2. Jornada | 20.01.2021 | Cerro Largo | - | Nacional | 0:0 | ||||
| 3. Jornada | 29.01.2021 | Boston River | - | Cerro Largo | 2:1 | ||||
| 6. Jornada | 10.02.2021 | Liverpool | - | Cerro Largo | 3:2 | |
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| 8. Jornada | 17.02.2021 | Cerro Largo | - | Peñarol | 1:1 | |
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| 9. Jornada | 20.02.2021 | River Plate | - | Cerro Largo | 2:0 | ||||
| 13. Jornada | 21.03.2021 | Fénix | - | Cerro Largo | 1:0 | |
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| 14. Jornada | 24.03.2021 | CA Cerro | - | Cerro Largo | 0:1 | ||||
| 15. Jornada | 29.03.2021 | Cerro Largo | - | Defensor Sporting | 0:0 |
Uruguay