| 3. Jornada | 22.01.2022 | Club León [Sub 18] | - | CF Pachuca [Sub 18] | 4:2 | ||||
| 8. Jornada | 02.03.2022 | Atlas Guadalajara [Sub 18] | - | CF Pachuca [Sub 18] | 2:1 | ||||
| 9. Jornada | 23.03.2022 | CF Pachuca [Sub 18] | - | UANL Tigres [Sub 18] | 4:0 | ||||
| 13. Jornada | 11.04.2022 | CF Pachuca [Sub 18] | - | Club Tijuana [Sub 18] | 1:2 | ||||
| 14. Jornada | 15.04.2022 | FC Juárez [Sub 18] | - | CF Pachuca [Sub 18] | 2:0 | ||||
| 15. Jornada | 19.04.2022 | CF Pachuca [Sub 18] | - | Puebla FC [Sub 18] | 3:0 | ||||
| 16. Jornada | 23.04.2022 | CF Pachuca [Sub 18] | - | CF Monterrey [Sub 18] | 2:1 | ||||
| 17. Jornada | 01.05.2022 | Pumas UNAM [Sub 18] | - | CF Pachuca [Sub 18] | 0:1 |  |
México