| 2. Jornada | 13.02.2022 | Real Santa Cruz | - | CD Guabirá | 2:2 |  |
|||
| 3. Jornada | 18.02.2022 | Nacional Potosí | - | Real Santa Cruz | 1:0 | ||||
| 4. Jornada | 26.02.2022 | Real Santa Cruz | - | The Strongest | 1:2 | ||||
| 5. Jornada | 06.03.2022 | Real Santa Cruz | - | Club Aurora | 2:2 | ||||
| 6. Jornada | 12.03.2022 | Real Santa Cruz | - | Always Ready | 0:1 | ||||
| 9. Jornada | 16.04.2022 | Universitario de Sucre | - | Real Santa Cruz | 2:3 | ||||
| 11. Jornada | 24.04.2022 | Real Santa Cruz | - | Nacional Potosí | 3:2 |  |
|||
| 12. Jornada | 30.04.2022 | The Strongest | - | Real Santa Cruz | 1:1 | ||||
| 15. Jornada | 14.05.2022 | Oriente Petrolero | - | Real Santa Cruz | 1:2 |
Bolivia