| 2. Jornada | 16.01.2022 | Atlas Guadalajara | - | Atlético San Luis | 1:0 | ||||
| 1. Jornada | 20.01.2022 | Club León | - | Atlas Guadalajara | 1:1 | ||||
| 3. Jornada | 23.01.2022 | CF América | - | Atlas Guadalajara | 0:2 | ||||
| 4. Jornada | 07.02.2022 | Atlas Guadalajara | - | Santos Laguna | 2:1 | ||||
| 6. Jornada | 21.02.2022 | Atlas Guadalajara | - | Pumas UNAM | 0:0 | ||||
| 7. Jornada | 26.02.2022 | Club Tijuana | - | Atlas Guadalajara | 2:0 | ||||
| 8. Jornada | 03.03.2022 | Atlas Guadalajara | - | CF Pachuca | 0:1 | ||||
| 9. Jornada | 06.03.2022 | Gallos Blancos | - | Atlas Guadalajara | 0:3 | ||||
| 10. Jornada | 12.03.2022 | FC Juárez | - | Atlas Guadalajara | 1:2 | ||||
| 12. Jornada | 03.04.2022 | Cruz Azul | - | Atlas Guadalajara | 1:0 | ||||
| 13. Jornada | 08.04.2022 | Atlas Guadalajara | - | Club Necaxa | 2:1 | ||||
| 14. Jornada | 15.04.2022 | Atlas Guadalajara | - | Mazatlán FC | 1:2 | ||||
| 15. Jornada | 21.04.2022 | CF Monterrey | - | Atlas Guadalajara | 0:0 | ||||
| 16. Jornada | 24.04.2022 | Deportivo Toluca | - | Atlas Guadalajara | 2:4 |  |
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| 17. Jornada | 01.05.2022 | Atlas Guadalajara | - | UANL Tigres | 1:1 |
México