| 2. Jornada | 24.07.2010 | Libertad | - | Tacuary | 3:0 | ||||
| 3. Jornada | 01.08.2010 | Sport Colombia | - | Libertad | 1:0 | ||||
| 5. Jornada | 15.08.2010 | Club Olimpia | - | Libertad | 0:2 |  |
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| 6. Jornada | 21.08.2010 | Libertad | - | Sportivo Trinidense | 7:0 | |
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| 7. Jornada | 28.08.2010 | Libertad | - | Guaraní | 2:0 | |
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| 8. Jornada | 05.09.2010 | Cerro Porteño | - | Libertad | 2:0 | ||||
| 9. Jornada | 12.09.2010 | Libertad | - | Club Nacional | 1:0 | |
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| 10. Jornada | 18.09.2010 | Sol de América | - | Libertad | 0:1 | |
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| 11. Jornada | 26.09.2010 | 3 de Febrero | - | Libertad | 2:1 | |
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| 12. Jornada | 03.10.2010 | Libertad | - | Sportivo Luqueño | 3:1 | |
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| 13. Jornada | 09.10.2010 | Tacuary | - | Libertad | 0:1 | |
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| 14. Jornada | 16.10.2010 | Libertad | - | Sport Colombia | 4:0 | |
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| 15. Jornada | 20.10.2010 | Club Rubio Ñu | - | Libertad | 1:3 | ||||
| 16. Jornada | 24.10.2010 | Libertad | - | Club Olimpia | 2:2 | |
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| 17. Jornada | 30.10.2010 | Sportivo Trinidense | - | Libertad | 1:2 | ||||
| 18. Jornada | 05.11.2010 | Guaraní | - | Libertad | 2:0 | ||||
| 19. Jornada | 14.11.2010 | Libertad | - | Cerro Porteño | 2:0 | ||||
| 20. Jornada | 21.11.2010 | Club Nacional | - | Libertad | 1:0 |
Paraguay