| 1. Jornada | 09.01.2022 | Pumas UNAM [Sub 18] | - | Deportivo Toluca [Sub 18] | 1:0 | ||||
| 2. Jornada | 14.01.2022 | Gallos Blancos [Sub 18] | - | Pumas UNAM [Sub 18] | 0:3 | ||||
| 14. Jornada | 27.01.2022 | Pumas UNAM [Sub 18] | - | CF Monterrey [Sub 18] | 4:2 |  |
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| 4. Jornada | 05.02.2022 | Club Tijuana [Sub 18] | - | Pumas UNAM [Sub 18] | 2:0 | ||||
| 5. Jornada | 13.02.2022 | Pumas UNAM [Sub 18] | - | Club León [Sub 18] | 0:0 | ||||
| 6. Jornada | 20.02.2022 | Atlas Guadalajara [Sub 18] | - | Pumas UNAM [Sub 18] | 5:2 | |
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| 7. Jornada | 26.02.2022 | Pumas UNAM [Sub 18] | - | CF América [Sub 18] | 0:1 | ||||
| 16. Jornada | 23.04.2022 | Deportivo Guadalajara [Sub 18] | - | Pumas UNAM [Sub 18] | 1:2 | ||||
| 17. Jornada | 01.05.2022 | Pumas UNAM [Sub 18] | - | CF Pachuca [Sub 18] | 0:1 |
México